Casamigos is best to experience on the rocks by the shot and, at times, straight from the bottle. Their idea was to create the best tasting, smoothest Tequilas and Mezcal, that don't have to cover up with salt or lime. So, they did. If you aren't one for straight-up liquor, Casamigos Blanco lends itself well when mixed into almost any tequila-based drink.